abstract：:In this article, we introduce the increasing prevalence of type 2 diabetes in the Japanese population and discuss the reasons for such an explosive increase. Diabetes has been brought into prominence in Japan by enhanced insulin resistance, through the change of lifestyle against the background of fragile beta-cell fu...

journal_title：Current diabetes reports

authors： Hirose T,Kawamori R

更新日期：2005-06-01 00:00:00

abstract：:Hyperglycemia and dyslipidemia are significant and independent risk factors for the vascular complications in patients with diabetes. They have been suggested to cause cardiovascular pathologic changes in diabetic states through the following molecular mechanisms: formation and accumulation of advanced glycation end p...

journal_title：Current diabetes reports

authors： Xu Y,He Z,King GL

更新日期：2005-04-01 00:00:00

abstract：:Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping ...

journal_title：Current diabetes reports

authors： Mohlke KL,Boehnke M

更新日期：2005-04-01 00:00:00

abstract：:Erectile dysfunction (ED) is more commonly seen in men with various components of the metabolic syndrome (a constellation of various cardiovascular and diabetes risk factors). ED can be considered as a risk marker of the metabolic syndrome and its associated conditions. The patient with ED should be thoroughly evaluat...

journal_title：Current diabetes reports

authors： Matfin G,Jawa A,Fonseca VA

更新日期：2005-02-01 00:00:00

abstract：:Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming growth factor-beta (TGF-beta) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies h...

journal_title：Current diabetes reports

authors： McGowan TA,Zhu Y,Sharma K

更新日期：2004-12-01 00:00:00

abstract：:Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...

journal_title：Current diabetes reports

authors： Karl DM

更新日期：2004-10-01 00:00:00

abstract：:Maintaining normal blood glucose levels is a constant challenge for women with diabetes. Anecdotal reports reveal that many women question if menstrual cycle phases may affect their blood glucose levels. However, results from studies investigating the effect of the menstrual cycle on insulin sensitivity in diabetic wo...

journal_title：Current diabetes reports

authors： Trout KK,Teff KL

更新日期：2004-08-01 00:00:00

abstract：:Type 2 diabetes is the result of a progressive impairment of pancreatic beta-cell function in the setting of worsening insulin resistance. Studies in high-risk populations have demonstrated that during progression to diabetes, beta cells have declining function and lose the first phase of insulin secretion, resulting ...

journal_title：Current diabetes reports

authors： Steppel JH,Horton ES

更新日期：2004-06-01 00:00:00

abstract：:The prevalence of diabetes is two- to threefold higher in American Indians in Montana compared with the non-Indian population. High rates of diabetes have also been described in Canadian aboriginal populations closely related to the tribes in Montana. Diabetes in pregnancy has increased among Indian mothers and high-b...

journal_title：Current diabetes reports

authors： Gohdes D,Oser CS,Harwell TS,Moore KR,McDowall JM,Helgerson SD

更新日期：2004-06-01 00:00:00

abstract：:There is a well-documented gap between research and practice in diabetes and many other chronic illnesses. This gap is due, in part, to limitations of the research database. Different types of clinical trials have recently been called for that address issues central to clinicians, administrative decision makers, and p...

journal_title：Current diabetes reports

authors： Glasgow RE

更新日期：2004-04-01 00:00:00

abstract：:Infections of the tissue surrounding the teeth (periodontitis) are usually caused by anaerobic gram-negative microorganisms. This infection causes destruction of the supporting alveolar bone and can lead to tooth loss. Removal of these microorganisms can slow or arrest the progression of periodontitis. Diabetes patien...

journal_title：Current diabetes reports

authors： Pucher J,Stewart J

更新日期：2004-02-01 00:00:00

abstract：:Although there is clear evidence from experimental diabetic neuropathy (DN) models that the multiple pathways involved in neuronal degeneration cause overproduction of reactive oxygen species, oxidative stress, and cellular dysfunction, therapeutic approaches addressing these mechanisms have not yet provided a basis f...

journal_title：Current diabetes reports

authors： Bierhaus A,Humpert PM,Rudofsky G,Wendt T,Morcos M,Hamann A,Nawroth PP

更新日期：2003-12-01 00:00:00

abstract：:National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

journal_title：Current diabetes reports

authors： Carson JA

更新日期：2003-10-01 00:00:00

abstract：:Cardiovascular disease is a leading cause of death and disability in patients with diabetes or metabolic syndrome (MS). The available data suggest that many patients with diabetes or MS already have vascular abnormalities by the time they are diagnosed with their metabolic disorder. Endothelial dysfunction (ED), which...

journal_title：Current diabetes reports

authors： Deedwania PC

更新日期：2003-08-01 00:00:00

abstract：:Both type 1 and type 2 diabetic patients have an increased incidence of ischemic heart disease and congestive heart failure. Cardiovascular disease accounts for up to 80% of the excess mortality in patients with type 2 diabetes. The burden of cardiovascular disease is especially pronounced in diabetic women. Factors t...

journal_title：Current diabetes reports

authors： Blendea MC,McFarlane SI,Isenovic ER,Gick G,Sowers JR

更新日期：2003-06-01 00:00:00

abstract：:This article reviews selected recent literature on adult diabetes patient-centered adherence to diabetes care recommendations. We describe more fully a limited number of articles that have particular lessons for diabetes clinicians and researchers. Each article was reviewed for methodology, adherence measures, and typ...

journal_title：Current diabetes reports

authors： Walker EA,Usher JA

更新日期：2003-04-01 00:00:00

abstract：:Microalbuminuria clusters with the metabolic syndrome, and both conditions predict cardiovascular disease mortality. The reported relationships of microalbuminuria with the individual components of the metabolic syndrome (i.e., hyperglycemia, insulin resistance, hypertension, dyslipidemia, abdominal obesity) are varia...

journal_title：Current diabetes reports

authors： Rowley K,O'Dea K,Best JD

更新日期：2003-02-01 00:00:00

abstract：:Hypertension and diabetes are independent risk factors for both cardiovascular disease and renal complications. Coexistence of these comorbid conditions predisposes the patient to a much greater risk of progression to end-stage renal disease. Combined with the increased cardiovascular mortality, this has led to recent...

journal_title：Current diabetes reports

authors： Newton CA,Raskin P

更新日期：2002-12-01 00:00:00

abstract：:Exercise has long been recognized as a cornerstone in diabetes care. Even so, modern science is just beginning to understand the physiologic impact cardiovascular fitness has on long-term diabetes management, and the prevention or delay, of type 2 diabetes. Recent advances in research are defining the metabolic pathwa...

journal_title：Current diabetes reports

authors： Mullooly C

更新日期：2002-10-01 00:00:00

abstract：:The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory,...

journal_title：Current diabetes reports

authors： Dandona P

更新日期：2002-08-01 00:00:00

abstract：:Impaired glucose tolerance (IGT) is characterized by plasma glucose responses to an oral glucose challenge that are above normal but not at the level defining diabetes. IGT is a common condition that greatly increases risk for the subsequent development of type 2 diabetes. Individuals with IGT manifest abnormalities i...

journal_title：Current diabetes reports

authors： Pratley RE,Weyer C

更新日期：2002-06-01 00:00:00

abstract：:Diabetes is a common complication of cystic fibrosis (CF), occurring in approximately 40% of adult patients. It is clinically distinct from type 1 or type 2 diabetes, and requires a unique approach. Because of evidence that it is associated with increased morbidity and mortality, prompt diagnosis and aggressive manage...

journal_title：Current diabetes reports

authors： Moran A

更新日期：2002-04-01 00:00:00

abstract：:Diabetes self-management education (DSME) has been shown to improve health outcomes. Yet, relatively little is known about how DSME has its effects. Literature reviewed from the past 3 years indicates that if DSME is to become more effective interventions need to be theory-based, to increase patient involvement in the...

journal_title：Current diabetes reports

authors： Williams GC,Zeldman A

更新日期：2002-04-01 00:00:00

abstract：:In nondiabetic individuals, a poor response to an endothelium-dependent vasodilator in coronary vessels has been shown to increase the likelihood of a future cardiovascular event. Such prospective data are not as yet available in patients with type 1 or type 2 diabetes. However, consistent with the greatly increased c...

journal_title：Current diabetes reports

authors： Mäkimattila S,Yki-Järvinen H

更新日期：2002-02-01 00:00:00

abstract：:Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....

journal_title：Current diabetes reports

authors： Adler A

更新日期：2001-12-01 00:00:00

abstract：:Diabetic nephropathy is the leading cause of renal failure in industrialized countries. There is strong evidence that diabetic nephropathy is influenced by genetic factors. Studies in the Pima Indians as well as in other populations demonstrate that diabetic nephropathy aggregates in families. The hypothesis that the ...

journal_title：Current diabetes reports

authors： Imperatore G,Knowler WC,Nelson RG,Hanson RL

更新日期：2001-12-01 00:00:00

abstract：:The insulin resistance syndrome (IRS) is a common disorder, which has important clinical implications. It is a cluster of cardiovascular risk factors that include obesity, hypertension, dyslipidemia, glucose intolerance, and type 2 diabetes mellitus. Lifestyle modifications and insulin sensitizers are among the severa...

journal_title：Current diabetes reports

authors： Desouza C,Gilling L,Fonseca V

更新日期：2001-10-01 00:00:00

abstract：:These data are a review of previously published data. Initially, body composition was estimated in 186 neonates. Fat- free mass (FFM), which constituted 86% of birth weight, accounted for 83% of the variance in birth weight; fat mass (FM), which constituted 14% of birth weight, accounted for 46% of the variance in bir...

journal_title：Current diabetes reports

authors： Catalano PM,Kirwan JP

更新日期：2001-08-01 00:00:00